Hot Flashes? Why Complete Menopause Relief Works Better

When most women start the perimenopausal transition, they quickly become aware of uncomfortable symptoms such as hot flashes, sleep disturbances, and mood swings. Many products offer relief, with some working significantly better than others.

When we developed Complete Menopause Relief, we turned to the science to ensure the product would deliver the promise on the label.

Research Matters

We selected the two ingredients in Complete Menopause Relief, rhapontic rhubarb and copaiba extract, which were tested in a clinical trial conducted at NC State. Competing products rely on the rhapontic rhubarb alone, but the clinical trial demonstrated that the combination of copaiba extract and rhapontic rhubarb provided significantly greater symptom relief compared to similar studies using rhubarb alone.

Background: Alpha vs. Beta Estrogen Receptors

Rhapontic rhubarb and copaiba extract work differently in the body. Both ingredients function as estrogen receptors, proteins that bind to estrogen and perform a specific function. There are two kinds of estrogen receptors: alpha and beta.

Estrogen receptor alpha (ERa) helps promote cell growth and division. It plays a key role in the menstrual cycle and helps breast tissue develop.

Estrogen receptor beta (ERb) modulates and balances growth. It also plays roles in brain function and bone health.

The balance between alpha and beta receptors can influence how that tissue responds to estrogen.

Why the Ingredient Combination Works Better Than Rhapontic Rhubarb Alone

While copaiba extract functions as both an alpha and beta estrogen receptor agonist, rhapontic rhubarb only binds to the beta estrogen receptor. The synergistic combination of copaiba extract and rhapontic rhubarb used in Complete Menopause Relief provides more complete system activation by binding to both alpha and beta estrogen receptors in addition to cannabinoid receptors.

The results of the study say it all: 90% of women reported up to an 80% reduction in the severity of 13 menopause symptoms in as little as 7 days.*

Benefit Broken Down by Ingredient

Curious what each ingredient does in the body? This chart breaks down how rhapontic rhubarb and copaiba extract address each of the common symptoms of menopause:

Table 1. Symptom response by ingredient
Symptoms	Rhubarb Extract	Copaiba	Response
Hot flashes	✔	✔	Early improvement within 18–21 days; full effect by 6–8 weeks.
Night sweats	✔	✔
Menstrual anxiety		✔
Negative mood		✔
Irritability	✔	✔	Decreases stress and anxiety by modulating HPA axis hormones†
Sleep disturbance	✔	✔
Exhaustion		✔	Improves blood flow and lipid profile†
Sexual frustration	✔	✔
Urinary tract complaints	✔	✔
Heart complaints		✔	Neuromodulation supports a healthy inflammatory response to restore normal function*
Vaginal dryness	✔	✔
Joint & muscle complaints / Headache		✔

Table 2. Body systems supported during menopause
Body Systems	Rhubarb Extract	Copaiba	Function in Menopause
Endocannabinoid system	✔	✔	Modulates immune response, inflammation, pain, and mood
Cardiovascular system	✔	✔	Regulates vascular flow and pressure and maintains healthy lipids
HPA axis		✔	Affects stress, sleep, reproductive health, libido, and hormone balance
Receptor agonists	Estrogen receptor agonist—ER beta	Estrogen receptor agonist—ER alpha and beta Cannabinoid receptor agonist—CB2	Modulate hormones and systems when activated

Complete Menopause Relief formula offers powerful, hormone-free relief for 13 major menopausal symptoms, including hot flashes, night sweats, mood swings, and sleep disturbances. This unique formula features rhapontic rhubarb, a phytoestrogen shown to reduce the severity of menopausal symptoms in 90% of women. Copaiba extract works synergistically with rhubarb to enhance its effects, interacting with both estrogen receptors and the CB2 receptors of the endocannabinoid system to support stress management, positive mood, and hormonal balance.*